EPFL/STI/LO
Expert in optofluidics and nonlinear imaging
Demetri Psaltis
EPFL
3DOptoChemiImage
Optofluidic 3D chemical imaging cytometry based on inline digital Coherent anti-Stoke Raman scattering (CARS) holography

EPFL/STI/LO
Expert in optofluidics and nonlinear imaging
Demetri Psaltis
EPFL
Peking University/Physics
Expert in nonlinear optics, ultrafast/nonlinear optical imaging and
spectroscopy
Kebin Shi
Peking University

Project Description

We propose to develop a compact optofluidic 3D imaging cytometry system for high throughput screening of micro-scale objects based on their chemical fingerprint. By properly designing the optical system and selecting two excitation laser beams, we take holographic pictures based on the emission of Coherent Anti-Stoke Raman scattering (CARS) from the objects. A 3D image of the each object can be then digitally reconstructed. 

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Notable publications

Coherent anti-Stokes Raman scattering holography: theory and experiment
P. S. Edwards, N. Mehta, et al
Journal of Nonlinear Optical Physics and Materials 21, 1250028 (2012)

Holographic coherent anti-Stokes Raman scattering bio-imaging
K. Shi, P. S. Edwards, et al
Biomedical Optics Express 3, 1744-1749 (2012)